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KMID : 1200020190430030302
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Diabetes & Metabolism Journal
2019 Volume.43 No. 3 p.302 ~ p.318
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Effectiveness of Exercise Intervention in Reducing Body Weight and Glycosylated Hemoglobin Levels in Patients with Type 2 Diabetes Mellitus in Korea: A Systematic Review and Meta-Analysis
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Jang Ji-Eun
Cho Yong-In
Lee Byung-Wan
Shin Ein-Soon
Lee Sun-Hee
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Abstract
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Background: This study aimed to assess the effectiveness of exercise intervention in reducing body weight and glycosylated hemoglobin (HbA1c) level in patients with type 2 diabetes mellitus (T2DM) in Korea.
Methods: Cochrane, PubMed, Embase, KoreaMed, KMbase, NDSL, KCI, RISS, and DBpia databases were used to search randomized controlled trials and controlled clinical trials that compared exercise with non-exercise intervention among patients with non-insulin-treated T2DM in Korea. The effectiveness of exercise intervention was estimated by the mean difference in body weight changes and HbA1c level. Weighted mean difference (WMD) with its corresponding 95% confidence interval (CI) was used as the effect size. The pooled mean differences of outcomes were calculated using a random-effects model.
Results: We identified 7,692 studies through literature search and selected 23 articles (723 participants). Compared with the control group, exercise intervention (17 studies) was associated with a significant decline in HbA1c level (WMD, ?0.58%; 95% CI, ?0.89 to ?0.27; I2=73%). Although no significant effectiveness on body weight was observed, eight aerobic training studies showed a significant reduction in body weight (WMD, ?2.25 kg; 95% CI, ?4.36 to ?0.13; I2=17%) in the subgroup analysis.
Conclusion: Exercise significantly improves glycemic control; however, it does not significantly reduce body weight. Aerobic training can be beneficial for patients with non-insulin-treated T2DM in Korea.
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KEYWORD
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Body weight, Exercise therapy, Glycated hemoglobin A, Meta-analysis, Review
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